1,n-Thiosulfonylation Using Thiosulfonates as Dual Functional Reagents

D. Ge,^a J.-W. Chen,^a Pei Xu,*^b Jinyin Pan,^c X.-Q. Chu*^a

^a Institute of Advanced Synthesis, School of Chemistry and Molecular Engineering, Nanjing Tech University, Nanjing 211816, China.

^b Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, School of Pharmacy, Xuzhou Medical University, Xuzhou 221004, China.

^c Sartorius Stedim (Shanghai) Trading Co., Ltd., Shanghai 200000, China.

Abstract: In recent years, the direct introduction of sulfonyl and sulfenyl groups into unsaturated substrates by using thiosulfonates as unique dual functional reagents has inarguably provided chemists a new platform for the diverse synthesis of important S-containing derivatives. These 1,n-thiosulfonylation reactions usually feature simple procedures, 100% atom economy, and high regioselectivity. This review focuses on the recent advancements in the transformations of thiosulfonates through 1,n-thiosulfonylation involving the formation of two distinct C-S bonds under transition-metal-catalyzed or metal-free conditions, where thiosulfonates act as both a sulfonyl and a sulfenyl component.

Chin. Chem. Lett. 2022, 33, 4732–4739, DOI: 10.1016/j.cclet.2022.02.019. (Impact factor: 8.455, Review)

论文链接：https://doi.org/10.1016/j.cclet.2022.02.019