Titanium(IV)-Mediated Ring-Opening/Dehydroxylative Cross-Coupling of Diaryl Substituted Methanols with Cyclopropanol Derivative

Si-Xuan Zhang,^† Yan Ding,^† Jun-Jie Wang,^† Chuanji Shen,^‡ Xiaocong Zhou,*^,‡ Xue-Qiang Chu,^† Mengtao Ma,^§ and Zhi-Liang Shen*^,†

^† Institute of Advanced Synthesis, School of Chemistry and Molecular Engineering, Nanjing Tech University, Nanjing 211816, China.

^‡ School of Pharmacy, Yancheng Teachers University, Yancheng 224007, China.

^§ Department of Chemistry and Materials Science, College of Science, Nanjing Forestry University, Nanjing 210037, China.

Abstract: A titanium(IV)-mediated ring-opening/dehydroxylative cross-coupling of diaryl substituted methanols with cyclopropanol derivative was developed. The reactions proceeded efficiently to provide synthetically useful γ,γ-diaryl esters in moderate to good yields, which could be applied to the functionalization of complex molecules derived from bioactive Fenofibrate and Isoxepac, as well as the synthesis of precursor of Zoloft.

J. Org. Chem. 2021, 86, 15753-15760.  (Impact factor: 4.35)

论文链接：https://pubs.acs.org/doi/10.1021/acs.joc.1c01790