Dehydrative Allylation of Alkenyl sp2 C-H Bonds

Xinying Cai^†, Huicong Xing^†, Ju Qiu^†, Bowen Li^†, and Peizhong Xie^†*

† School of Chemistry and Molecular Engineering, Nanjing Tech University, Nanjing 211816, P. R. China.

Abstract: We designed a cooperative catalytic system by combining commercially available Ca(NTf₂)PF₆ and Pd(PPh₃)₄ to address the dehydrative allylation of alkenyl sp² C-H bonds in an environmentally benign manner. A novel C-OH bond cleavage method was found to be crucial for this practical protocol. A variety of alkenes and allylic alcohols equipped with wide-spectrum functional groups can be successfully incorporated into the desired cross-coupling, affording 1,4-dienes with moderate to excellent yields and high stereo- and regioselectivity.

Org. Lett. 2021, 23, 4368-4373.（影响因子：6.005）

论文链接：https://pubs.acs.org/doi/10.1021/acs.orglett.1c01309