Palladium-Catalyzed Direct Arylation of 2-Pyridylmethyl Silanes with Aryl Bromides

Tingzhi Lin,¹ Pengcheng Qian, ¹ Yan-En Wang, ² Mingjie Ou, ¹ Long Jiang, ³ Chen Zhu, ¹ Yuchuan Xu, ¹ Dan Xiong,¹ and Jianyou Mao,*^{, 1}

¹Technical Institute of Fluorochemistry (TIF), Institute of Advanced Synthesis, School of Chemistry and Molecular Engi-neering, Nanjing Tech University, 30 South Puzhu Road, Nanjing 211800, P. R. China.

²College of Science, Hebei Agricultural University, Baoding 071000, P. R. China.

³Institute of Advanced Synthesis (IAS), Northwestern Polytechnical University (NPU), Xi'an, 710072, China. Yangtze River Delta Research Institute of NPU, Taicang Jiangsu, 215400, P. R. China.

Abstract: The first palladium-catalyzed direct arylation of 2-pyridylmethyl silanes with aryl bromides to generate a diverse array of aryl(pyridyl)-methyl silane derivatives has been developed. This protocol facilitates access to various kinds of heterocycle-containing silanes in good to excellent yields (40 examples, 66−97% yield) with good functional group tolerance. The scalability of this transformation is demonstrated.

DOI:10.1021/acs.orglett.1c00677 (2020年影响因子: 6.091).

论文链接：https://pubs.acs.org/doi/10.1021/acs.orglett.1c00677