李 伟，博士，副教授，硕士生导师  

Email:  liwei93@njtech.edu.cn

个人简历：

2023.12 - 至今， 南京工业大学，美高梅mgm1888公司官网，副教授

2023.05 - 2023.10 湖南大学，化学化工学院，副研究员

2020.11 - 2023.10 湖南大学，化学化工学院，博士后

2015.09 - 2020.10 湖南大学，化学化工学院，理学博士(硕博)，导师：袁林教授

2011.09 - 2015.06 湖北理工学院，化学与化工学院，工学学士

研究方向：

围绕生物医学成像研究和体外诊断的需求，结合染料结构性能调控、生物分子识别策略与纳米功能化技术，开发高特异性、高灵敏的新型生物探针，为新型生物分子的精准检测与成像分析提供有力工具。

1）开发光学成像新平台、特异性识别策略，构建新型生物标志物的光学(荧光、余辉等)探针

2）光学探针的纳米功能化及其成像分析与诊疗应用研究

3）开发新型精准快速的化学生物传感器件，满足体外诊断与现场即时检测

学术成绩：

至今以第一作者（或共一）或通讯作者发表SCI论文10余篇，包括化学TOP期刊J. Am. Chem. Soc.、Angew. Chem. Int. Ed.及其他化学权威期刊（Chem. Sci.、Anal. Chem. (2篇)、ACS Sens.、Chem. Comm.、Chinese. Chem. Lett.等，其中影响因子大于6的论文10篇，一区的论文7篇。并受邀担任Anal. Chem.、Theranostics、BBA - Molecular Basis of Disease等国际期刊的审稿人。

科研项目：

江苏省自然科学基金 青年基金项目，2024-2027，主持

江苏省高等学校自然科学基金 面上项目，2024-2026，主持

化学生物传感与计量学国家重点实验室（湖南大学）开放基金，2024-2025，主持

中国博士后科学基金面上项目，2021-2023，主持

国家自然科学基金重点项目，2023-2027，参与

代表性论文：

1）Li Wei; Yin Shulu; Shen Yang; Li Haiyan; Yuan Lin*; Zhang Xiao-Bing*. Molecular engineering of pH-responsive NIR oxazine assemblies for evoking tumor ferroptosis via triggering lysosomal dysfunction. Journal of the American Chemical Society, 2023, 145, 6, 3736-3747. (IF= 15.0，中科院一区) DOI: 10.1021/jacs.2c13222

2）Shen Yang^‡, Li Wei ^‡, Zhou Zhixuan, Xu Junchao, Li Yuhang, Li Haiyan, Zheng Xudong, Liu Sulai*, Zhang Xiao-Bing, and Yuan Lin*. Dual-Locked fluorescent probes activated by aminopeptidase N and the tumor redox environment for high-precision imaging of tumor boundaries. Angewandte Chemie International Edition, 2024, e202406332. (共同一作，IF= 16.6，中科院一区) DOI: 10.1002/anie.202406332

3）Li Wei^‡; Wang Lu^‡; Yin Shulu; Lai Huanhua; Yuan Lin*; Zhang Xiaobing. Engineering a highly selective probe for ratiometric imaging of H₂S_n and revealing its signaling pathway in fatty liver disease. Chemical Science, 2020, 11, 7991-7999. (IF = 9.97，中科院一区) DOI: 10.1039/d0sc03336g

4）Li Wei; Shen Yang; Gong Xiangyang; Zhang Xiao-Bing; and Yuan Lin*. Highly selective fluorescent probe design for visualizing hepatic hydrogen sulfide in the pathological progression of nonalcoholic fatty liver. Analytical Chemistry, 2021, 93, 16673−16682. (IF= 8.01，中科院一区) DOI: 10.1021/acs.analchem.1c04246

5）Li Wei; Yin Shulu; Gong Xiangyang; Xu Wang; Yang Ronghua; Wan Yichao; Yuan Lin*; Zhang XiaoBing. Achieving the ratiometric imaging of steroid sulfatase in living cells and tissues with a two-photon fluorescent probe. Chemical communications, 2020, 56, 1349-1352. (IF= 6.06，中科院二区) DOI: 10.1039/c9cc08672b

6）Li Wei; Gong Xiangyang; Fan Xiaopeng; Yin Shulu; Su Dongdong*; Zhang Xiaobing; Yuan Lin*. Recent advances in molecular fluorescent probes for organic phosphate biomolecules recognition. Chinese Chemical Letters, 2019, 30, 1775-1790. (IF= 8.46，中科院一区) DOI: 10.1016/j.cclet.2019.07.056

7) Wu Qian^‡; Zhou Qian-Hui^‡; Li Wei*; Ren Tian-Bing; Zhang Xiao-Bing; Yuan Lin*. Evolving an ultra-sensitive near-infrared β-galactosidase fluorescent probe for breast cancer imaging and surgical resection navigation. ACS Sensors, 2022, 7, 3829-3837. (IF= 9.62，中科院一区) DOI: 10.1021/acssensors.2c01752

8) Peng Chao; Yang Jinfeng; Li Wei*; Lin Dan; Fei Yanxia; Chen Xiaolan; Yuan Lin; Li Yinhui*. Development of a high signal-to-noise probe based on the facile modification of xanthene dye for imaging peroxynitrite during liver ischemia and reperfusion process. Analytical Chemistry, 2022, 94, 10773-10780, (IF= 8.01，中科院一区) DOI: 10.1021/acs.analchem.2c01496

9) Su Liang; Yang Feiyu; Li Wei*; Li Haiyan; Wang Chunjiang; Wang qiuan*; Yuan Lin*. Engineering a selective fluorescent sensor with high signal-to-background ratio for microalbumin detection and imaging. Materials Chemistry Frontiers, 2022, 6, 3084-3093. (IF= 8.68，中科院二区) DOI: 10.1039/d2qm00392a

10) Shen Yang; Zhou Qianhui; Li Wei*; and Yuan Lin*. Advances in optical imaging of nonalcoholic fatty liver disease. Chemistry-an Asian Journal, 2022, 17, e202200320. (IF= 4.84) DOI: 10.1002/asia.202200320

11) Gong Xiangyang; Cheng Dan*; Li Wei*; Shen Yang; Peng Rong; Shi Ling*; He Longwei*; Yuan Lin. A highly selective ratiometric molecular probe for imaging peroxynitrite during drug-induced acute liver injury. Journal of Materials Chemistry B, 2021, 9, 8246-8252. (IF= 6.33，中科院二区) DOI: 10.1039/d1tb01534f

12) Li Haiyan; Sheng Yang; Li Wei*; and Yuan Lin*. Recent advances in molecular fluorescent probes for CYP450 sensing and imaging. Chemosensors, 2022, 10, 304. (IF= 4.29) DOI: 10.3390/ chemosensors10080304

13) Li Haiyan; Sheng Yang; Zhengkun Dong, Li Wei*; and Yuan Lin*. Rational design of tunable near-infrared oxazine probe with large stokes shift for leucine aminopeptidase detection and imaging. Chemistry-an Asian Journal, 2023, 18, e202300701. (IF= 4.84) DOI: 10.1002/asia.202300701

相关链接: ORCID iD https://orcid.org/0000-0001-6694-3368