个人网页：http://www.researcherid.com/rid/H-7940-2016  

教育和工作经历

2017年4月起    美高梅mgm1888公司官网，教授

2014-2017年    英国布里斯托大学化学院，博士后

2010-2014年    西班牙加泰罗尼亚化学研究所（ICIQ），博士

2007-2010年    中国人民大学化学系，硕士

2002-2006年    兰州大学化学化工学院，学士

学术成绩

自2017年独立工作以来，研究方向集中于：以醇、糖、羧酸等廉价易得的基本化学品为原料，利用温和的电化学手段为关键步骤，高效合成有机功能分子及药物中间体。发表的主要基础研究工作包括：电化学氧化脱羧、脱氢、脱羟基构建Csp³–N、Csp³–Csp²键及其机理的DFT计算研究；电化学脱氧还原、脱氧负离子生成等方法；受邀撰写有机电化学合成领域综述3篇。在应用研究方面：将电化学脱羧策略应用于合成降血脂药物‘贝派地酸’，提高了总收率，获得中国专利授权1项；成功开发出治疗2型糖尿病肾脏病新药‘非奈利酮’起始物料的新方法，并实现了非奈利酮异构体的电化学回收策略，降低了成本。先后承担国家自然科学基金青年项目、江苏省自然科学基金青年项目、南京市留学人员科技创新择优资助等项目，并分别于2015年入选欧盟“玛丽居里学者计划”，2018年入选国家人社部“高层次留学人才回国资助计划”，2022年入选江苏省“科技副总”等人才项目。迄今已发表包括Science、J. Am. Chem. Soc.、Angew. Chem. Int. Ed.等论文40余篇，被引1500余次，其中ESI高被引论文2篇；申请发明专利7项，已授权3项。

研究方向

有机电化学合成、药物合成

代表性论文

24. Meng Li, Yue Tian, Kunhui Sun, Zhimin Xu, Lifang Tian*, Yahui Wang*, “Electrochemical deoxygenative arylation of aldehydes and ketones” Chem. Commun. 2023, 59, (37), 5587–5590.

23. Zhihui Wang, Xiaoqian Zhao, Hongyu Wang, Xiuyun Li, Zhimin Xu, Velayudham Ramadoss, Lifang Tian*, Yahui Wang*, “Dehydroxylative Arylation of Alcohols via Paired Electrolysis” Org. Lett. 2022, 24, (40), 7476–7481.

22. Kunhui Sun, Zhimin Xu, Velayudham Ramadoss, Lifang Tian*, Yahui Wang*, “Electrochemical deoxygenative reduction of ketones” Chem. Commun. 2022, 58, (79), 11155–11158.

21. Li-Li Zhu, Lifang Tian, Kunhui Sun, Yiwen Li, Guanglu Liu, Bin Cai, Hui Zhang*, Yahui Wang*, “N²-Selective β-Thioalkylation of Benzotriazoles with Alkenes” J. Org. Chem. 2022, 87, (19), 12963–12974. (Supplementary Cover).

20. Yue Zheng, Lifang Tian, Velayudham Ramadoss, Hui Zhang, Li-Li Zhu*, Yahui Wang*, “Recent Developments in N²-Selective Functionalizations of 1,2,3-Triazoles” Synthesis 2022, 54, (11), 2548–2560.

19. Hongyu Wang, Zhihui Wang, Guo Zhao, Velayudham Ramadoss, Lifang Tian*, Yahui Wang*, “Electrochemical Deoxygenative Barbier-Type Reaction” Org. Lett. 2022, 24, (20), 3668–3673.

18. Zhimin Xu, Yue Zheng, Lifang Tian*, Yahui Wang*, “Synthesis of Bempedoic Acid through Electrochemical Decarboxylation of Dialkylated Malonic Acid” Synthesis 2021, 53, (19), 3608–3612.

17. Haiwen Meng, Kunhui Sun, Zhimin Xu, Lifang Tian*, Yahui Wang*, “P^(III)-Assisted Electrochemical Access to Ureas via in situ Generation of Isocyanates from Hydroxamic Acids” Eur. J. Org. Chem. 2021, (11), 1768–1772. (Highlighted by WileyChem公众号).

16. Shuo Wang, Zhimin Xu, Yahui Wang*, LifangTian*, “DFT investigation of the triphenylphosphine-assisted electrochemical dehydroxylative transformations” Mol. Catal. 2021, 504, (3), 111470.

15. Velayudham Ramadoss⁺, Yue Zheng⁺, Xiaoqing Shao, Lifang Tian*, Yahui Wang*, “Advances in Electrochemical Decarboxylative Transformation Reactions” Chem. Eur. J. 2021, 27, (10), 3213–3228.

14. Xiaoqing Shao, Yue Zheng, Velayudham Ramadoss, Lifang Tian*, Yahui Wang*, “Recent advances in P^III-assisted deoxygenative reactions under photochemical or electrochemical conditions” Org. Biomol. Chem. 2020, 18, (31), 5994–6005.

13. Yue Zheng, Xiaoqing Shao, Velayudham Ramadoss, Lifang Tian*, Yahui Wang*, “Recent Developments in Photochemical and Electrochemical Decarboxylative C(sp³)-N Bond Formation” Synthesis 2020, 52, (9), 1357–1368. (Thieme Chemistry 高被引论文 in 2020–2021).

12. Li-Li Zhu, Lifang Tian, Bin Cai, Guanglu Liu, Hui Zhang*, Yahui Wang*, “Diamine-mediated N²-selective β-selenoalkylation of triazoles with alkenes” Chem. Commun. 2020, 56, (20), 2979–2982. DOI: 10.1039/d0cc00601g, 2020-03-11, (Back Cover).

11. Zhimin Xu⁺, Yue Zheng⁺, Zhihui Wang, Xiaoqing Shao, Lifang Tian*, Yahui Wang*, “Triphenylphosphine-assisted dehydroxylative Csp³-N bond formation via electrochemical oxidation” Chem. Commun. 2019, 55, (100), 15089–15092.

10. Enhui Ji, Haiwen Meng, Yue Zheng, Velayudham Ramadoss, Yahui Wang*, “Copper-Catalyzed Stereospecific Hydroboration of Internal Allylic Alcohols” Eur. J. Org. Chem. 2019, (44), 7367–7371.

9. Xiaoqing Shao⁺, Yue Zheng⁺, Lifang Tian⁺, Inmaculada Martín-Torres, Antonio M. Echavarren*, Yahui Wang*, “Decarboxylative Csp³-N Bond Formation by Electrochemical Oxidation of Amino Acids” Org. Lett. 2019, 21, (22), 9262–9267.

8. Xiaoqing Shao⁺, Lifang Tian⁺, Yahui Wang*, “C-N Coupling of Azoles or Imides with Carbocations Generated by Electrochemical Oxidation” Eur. J. Org. Chem. 2019, (25), 4089–4094.

7. Li-Li Zhu*, Lifang Tian, Hui Zhang, Lina Xiao, Wen Luo, Bin Cai, Haifeng Wang, Chunjie Wang, Guanglu Liu, Chaoyu Pei, Yahui Wang*, “Zinc-Catalysed N-Iodosuccinimide-Enabled Selective N²-Olefination of Benzotriazoles with Alkenes” Adv. Synth. Catal. 2019, 361, (5), 1117–1123.

6. Alexander Fawcett, Johan Pradeilles, Yahui Wang, Tatsuya Mutsuga, Eddie L. Myers, Varinder K. Aggarwal*, “Photoinduced decarboxylative borylation of carboxylic acids” Science 2017, 357, 283–286. (ESI Highly Cited Paper)

5. Yahui Wang, Adam Noble, Christopher Sandford, Varinder K. Aggarwal*, “Enantiospecific Trifluoromethyl-Radical-Induced Three-Component Coupling of Boronic Esters with Furans” Angew. Chem. Int. Ed. 2017, 56, 1810–1814. (IF=15.336)

4. Yahui Wang, Adam Noble, Eddie Myers, Varinder K. Aggarwal*, “Enantiospecific Alkynylation of Alkylboronic Esters” Angew. Chem. Int. Ed. 2016, 55, 4270–4274. (Highlighted by Synfacts)

3. Yahui Wang, Michael E. Muratore, Antonio M. Echavarren*, “Gold Carbene or Carbenoid, is there a Difference?” Chem. Eur. J. 2015, 21, 7332–7339. (ESI Highly Cited Paper)

2. Yahui Wang, Michael E. Muratore, Zhouting Rong, Antonio M. Echavarren*, “Formal (4+1) Cycloaddition of Methylencyclopropanes with 7-Aryl-1,3,5-cycloheptatrienes by Triple Gold(I) Catalysis” Angew. Chem. Int. Ed. 2014, 53, 14022–14026. (Hot Paper)

1. Yahui Wang, Paul R. McGonigal, Bart Herlé, Maria Besora, Antonio M. Echavarren*, “Gold(I) Carbenes by Retro-Buchner Reaction: Generation and Fate” J. Am. Chem. Soc. 2014, 136, 801–809.

王亚辉 教授

Email:ias_yhwang@njtech.edu.cn